Aging

NAD+ decline is one of the hallmarks of aging. Can restoring NAD+ levels with supplements actually slow down the aging process? Here’s what the science says. The NAD+ Aging Connection NAD+ levels decline dramatically with age: Age Relative NAD+ Level 20-30 100% (baseline) 40 ~50% 50 ~40% 60+ ~20-30% This decline contributes to many age-related problems: Reduced cellular energy — Cells can’t produce enough ATP Impaired DNA repair — More mutations accumulate Mitochondrial dysfunction — Powerhouses of cells decline Increased inflammation — Chronic low-grade inflammation (inflammaging) Sirtuin inactivation — Longevity genes become less active How NAD+ Affects Aging 1. Sirtuins (Longevity Genes) Sirtuins are a family of proteins that require NAD+ to function. They regulate: ...