NAD+ plays a crucial role in immune function. Here’s how it affects your body’s defenses.

NAD+’s Role in Immunity

1. Immune Cell Function

NAD+ is essential for:

  • T cell activation and proliferation
  • Natural killer cell activity
  • Macrophage function
  • Inflammatory response regulation

2. Inflammation Regulation

NAD+-dependent enzymes (sirtuins) regulate inflammation:

  • SIRT1 reduces inflammatory cytokines
  • SIRT3 protects immune cells from oxidative stress
  • Proper NAD+ levels prevent chronic inflammation

3. Cellular Repair

Immune cells need NAD+ for:

  • DNA repair after fighting infections
  • Mitochondrial function
  • Cellular energy production

Research Findings

NMN and Immunity

2021 (Nature Communications):

  • NMN enhanced T cell function in aged mice
  • Improved vaccine response
  • Restored immune function declined by aging

NR and Immunity

2020 (Nature Communications):

  • NR improved immune response in COVID patients
  • Reduced inflammatory markers
  • Enhanced recovery

Practical Implications

For General Immune Support

  • NMN 500mg or NR 300mg daily
  • Morning supplementation
  • Consistent use for best results

For Older Adults

  • Higher doses may be needed (NMN 1000mg, NR 600mg)
  • NAD+ decline is more significant with age
  • Immune benefits may be more pronounced