Leading research institutions are actively studying NAD+ for longevity. Here’s what they’re finding.

Harvard Medical School (Dr. David Sinclair)

Key Findings

  • NMN reversed age-related vascular dysfunction in mice
  • Restored muscle NAD+ levels to youthful levels
  • Improved exercise capacity in aged animals
  • Enhanced blood flow through capillary formation

Current Research

  • Human clinical trials on NMN and aging biomarkers
  • Studies on NMN and cardiovascular health
  • Research on optimal dosing protocols

MIT (Dr. Leonard Guarente)

Key Findings

  • Sirtuins (NAD+-dependent enzymes) regulate aging
  • NAD+ activates sirtuins, promoting cellular health
  • Resveratrol enhances sirtuin activation
  • NAD+ decline is a hallmark of aging

Current Research

  • NAD+ and neurodegeneration
  • Sirtuin biology
  • NAD+ precursor combinations

University of Washington (Dr. Shin-ichiro Imai)

Key Findings

  • NMN improved insulin sensitivity in aged mice
  • Enhanced immune function
  • Improved eye function
  • Restored gene expression patterns to younger profiles

Current Research

  • Long-term NMN safety in humans
  • NMN and age-related diseases
  • Optimal NMN formulations

Other Notable Research

Mayo Clinic

  • Senolytics + NAD+ precursors for aging
  • Combined interventions for longevity

Karolinska Institute

  • NAD+ and mitochondrial diseases
  • NR clinical applications

University of Cambridge

  • NAD+ and neurodegeneration
  • Brain-specific NAD+ metabolism

Where the Science is Heading

Near-term (1-3 years)

  • More human clinical trials
  • Better understanding of optimal dosing
  • Personalized NAD+ protocols

Medium-term (3-10 years)

  • FDA-approved anti-aging interventions
  • Combination therapies
  • Biomarker-guided supplementation

Long-term (10+ years)

  • Potential lifespan extension interventions
  • Disease prevention protocols
  • Precision longevity medicine