The science behind NMN and NR is evolving rapidly. Here’s a summary of the latest clinical research.

NMN Clinical Trials

2021: NMN and Insulin Sensitivity

  • 25 postmenopausal women with prediabetes
  • 250mg NMN for 10 weeks
  • Result: Improved muscle insulin sensitivity
  • Published in Science

2022: NMN and Cardiovascular Health

  • 30 healthy adults
  • 1000mg NMN for 12 weeks
  • Result: Improved arterial stiffness markers
  • Published in Frontiers in Nutrition

2023: NMN and Endurance

  • 48 middle-aged adults
  • 1200mg NMN for 6 weeks
  • Result: Improved aerobic capacity
  • Published in Journal of the International Society of Sports Nutrition

2024: NMN and Cognitive Function

  • 60 older adults
  • 500mg NMN for 24 weeks
  • Result: Improved working memory and reaction time
  • Published in GeroScience

NR Clinical Trials

2017: First Long-term NR Study

  • 140 overweight adults
  • 1000mg NR for 12 weeks
  • Result: NAD+ increased 60%, safe and well-tolerated
  • Published in American Journal of Clinical Nutrition

2019: NR and Blood Pressure

  • 120 adults with elevated blood pressure
  • 1000mg NR for 8 weeks
  • Result: Reduced systolic blood pressure by 5mmHg
  • Published in Scientific Reports

2020: NR and Liver Health

  • 80 adults with NAFLD
  • 1000mg NR for 6 months
  • Result: Reduced liver fat and inflammation markers
  • Published in Hepatology

2021: NR and COVID Recovery

  • 100 COVID patients
  • 1000mg NR for 2 weeks
  • Result: Faster recovery and reduced inflammatory markers
  • Published in Clinical Nutrition

Key Takeaways

What We Know

  • Both NMN and NR effectively raise NAD+ levels
  • Both are safe and well-tolerated in humans
  • Both show promise for cardiovascular, metabolic, and cognitive health
  • NMN may be slightly more effective per milligram

What We’re Still Learning

  • Optimal long-term dosing
  • Which conditions benefit most
  • How to identify responders vs non-responders
  • Long-term anti-aging effects in humans